Phil Pharmawealth/Atlantic Adrenaline Adverse Reactions

Adrenaline is a potent sympathomimetic and may exhibit the adverse effects typical of both alpha- and beta-adrenoceptor stimulation. Adverse effects such as anxiety, dyspnoea, hyperglycaemia, restlessness, palpitations, tachycardia (sometimes with anginal pain), tremors, sweating, hypersalivation, weakness, dizziness, headache, and coldness of extremities may occur even with low doses. Since adrenaline does not readily cross the blood-brain barrier, its central effects may be largely a somatic response to its peripheral effects. Overdosage may cause cardiac arrhythmias and a sharp rise in blood pressure (sometimes leading to cerebral haemorrhage and pulmonary oedema); these effects may occur at normal dosage in susceptible subjects.
Adrenaline is a potent vasoconstrictor and gangrene may occur if adrenaline-containing local anaesthetic solutions are infiltrated into digits. Extravasation of parenterally administered similarly causes intense vasoconstriction, resulting in tissue necrosis and sloughing.